منابع مشابه
Target organ toxicity: liver and kidney
The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated between the years 1975-1981 for Stage I and II breast cancer. One hundred and twenty seven patients (35%) have strongly positive, granular staining, 138 (38%) are intermediately stained in the cytoplasm, and in 94 (...
متن کاملIntroduction—target organ toxicity
The effects of progressive cachexia on protein metabolism in skeletal muscle has been investigated in mice bearing the MAC 16 adenocarcinoma which produces cachexia with tumour burdens of <1% of the host weight. Weight loss was accompanied by loss of whole body nitrogen in proportion to the overall loss of body mass. Using L-[4-3H]phenylalanine to label proteins in gastrocnemious muscle, a sign...
متن کاملTarget organ toxicity: lung introduction.
Continuous intravenous (i.v.) infusion of 5-fluorouracil (5-FU) has been shown to be superior to bolus regimens in terms of response rates and toxicity. However, a continuous infusion is more expensive and prone to complications such as thromboembolism and infections. A way to circumvent these problems would be to administer 5-FU subcutaneously (s.c.). To assess feasibility and bioavailability ...
متن کاملTarget organ toxicity: nervous system.
This conference was organized in response to the resurgence of interest in the behavioral and neurological effects resulting from low-level exposures to a wide variety of chemical and physical agents. One factor in this renewed interest was the passage of the Toxic Substance Control Act. This law specifically states, among other things, that chemicals should be evaluated for their behavioral ef...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1976
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.76151